In the past I have used the Skype Email Toolbar for Microsoft outlook. This gave me the ability to make Skype calls from my outlook user interface.
Last week Skype realised Skype 6.1 for windows Desktop with Outlook Integration which provides some nice integration features between Skype and Outlook 2010.
When I downloaded and installed the Skype update, I found the promised features did not work. Many others found the same issue.
The solution was to make a registry change, and now all works as expected.