chevrolux: In a patch panel situation we quit often drill of series of 50mm+ holes through the top plate and normally atleast one dwang. Never been an issue and never will. You aren't drilling holes every 100mm so it isnt going to weaken a bit of 4x2 much at all.
With due respect that's not your call to make, unless you are aware of the engineering design intention of the framework. Whilst the building inspector may not find that you've gouged out 55% of the cross section, if there was a subsequent building failure and the insurance company investigated it, they may have some questions to ask.
Chances of that happening though? Slim to none.