D.W:
My question is more around thermally broken alum vs uPVC, and if one is cheaper than the other. Also, if I have sufficient ventilation (such as HRV) is that going to significantly reduce condensation if I just had standard aluminium frames with double glazing?
Last time I looked at them pricing was similar, but check the market. PVC is white, aluminum can be colors. PVC is fairly robust, but can need a bit more maintenance if it gets something on it like bird droppings you may have to use jif to clean it. I've had PVC for ten years, it's very rare you need to do that, but does happen. I prefer PVC, but will get an aluminum / fiberglass front door for the color.
Not having had it, my guess is a ventilation system will reduce condensation if you have non-thermally broken joinery but not eliminate it. Regardless of what you do there will still be moisture inside, and the joinery will still be colder than ambient causing condensation.
I'd go thermally broken or PVC which doesn't need it. Additional cost not really that much when you consider the life of it.