mecow: MediaMonkey for everything music related. From iphone sync to complete organisation. With MediaMonkey you can get it to automatically move all music to folders based on tag info (once you have automatically updated all tag info obviously). Also is great for finding album art!
Its other major plus is the fact that it isn't a slug on my reasonably fast computer like itunes is.
VLC for all other media.
+1 for MM and VLC. As Mecow say, works well with a variety of MP3 players ( Samsung, Ipods, etc)
Tried Itunes once. Never again. Totally messed up my library, importing and downloading covers and descriptions, and overwriting what I had already painstakingly tagged. Maybe there were settings that prevented something like that from happening, but if that was Itunes default settings, gah !!!
Been making tentative forays into Win7's WMC as a media player - I do like the large clear layout for navigation, and is touch-screen friendly. However, a colleague recommends Ultimate Jukebox as a touch-enabled media player, so that is also on the test list. Whichever one that my aged and half-blind Mum can work out how to use will be the winner - the ultimate in user friendly-ness ..