Oblivian:
Turns out you may not be alone.
6 month old issue with a recent post by Epson
ii Please Run the Epson Scan Application as Administrator .this is temporary solution Epson will come back with new Scan application version.
This Is affected only to windows 10 1803 Users.
Worth a shot nigel. I've seen apps like this. Won't go unless explicitly run as admin despite being admin
Or the old compatibility.. https://www.tenforums.com/drivers-hardware/109669-epson-v300-not-working-properly-after-april-update-4.html
Guess what? Tried that LOL , and still no luck. Also found out, very recently, that my Event Manager does not work either.