I Would make the office open off the main room/lounge Kitchen etc,
It keeps it connected to the rest of the House, especially if you are spending a lot of time in there and SO in in the main room.
Having to go through two doors means the you are unlikely to be able to hear any "hey" from the lounge.... It also means you feel connected.... If you want to be "dis-connected" then just keep the slide door closed.



