guttedgeek: Heyall, great discussion for me as I'm going through a similar process myself (although with lower spec'd hardware).
One question I have is what are the benefits of the HTPC cases with extra buttons/function wheels/LED screens? I was looking at a fairly basic Silverstone case but this discussion has got me thinking - "what am I missing"?
I'm using Media Portal/TVServer - do they work at all with these additional features?
I have the Silverstone GD01B-MXR, and before that I had the Silverstone LC11S-M both had the Soundgraph front panel, no knobs or buttons other than the power and reset switch.
The advantage to having the front panel is the built in Infrared sensor which is constantly powered, this allows for a remote to turn the computer on and off and also mouse/keyboard input via the same remote. Other than that it is just an information screen, telling you the time, date, computer specs, news, weather, graphic eq, and can also do RSS feeds. But otherwise mine goes bung every other day and displays garbage (driver issue in Vista x64) but still works for on/off duties.
I have three remotes, TV, Computer, and Microsoft Media Center keyboard. To turn on I do TV on, Computer on, then those remotes sit and do nothing at all as Microsoft Media Keyboard does the rest with no problems. Wife is happy.
My sound is controlled via Media Center remote as it is analgue output from Auzentech X-Meridian 7.1 soundcard to Creative Gigaworks 7.1 speakers. If you use SPDIF then I believe the volume will be controlled via your amp.
Cheers
DB
Edit: You best bet for a case is something you like the look of, will fit well with your current setup or future upgrades, and most of all fit each and every part in with ease so it can perform it's duty correctly. Heat is a huge problem for Media Center PC's as the cases are normally small, in cramped locations without good airflow, and require the use of additional parts like riser cards or similar which restrict airflow through the case and just cause more heat and noise problems.