Looks like the font-smoothing thing prefers certain fonts over others. I've had a quick blat around the net and some sites look really good (of course the Apple site does) whilst others look heinous. Bold fonts seem to take a hammering. I'm using a 19" LCD and it looks like the "Light" rendering may be the best for me. Is this how people using Macs see the net?
Also, Safari doesn't play nice with Windows Live - whether it be the personalised Live home or even Spaces. It drops your formatting and personalised settings.