Rosetta is a memory hog alright, first day i started i was sitting at 90% usage on a 16gb machine, and 28gb of committed space. tweeked a few settings and its been a bit better behaved.
Folding is hit an miss for work units, had 2 the other night, and the had one finish and go into a long loop trying to send it back, the thing is you loose points for taking longer to send it back. it was stuck trying to contact an offline server. nothing was changing that. just let me queue a days worth of units (6-8) and it will be fine