Professional machines are not cheap.
The big names are LPFK and T-TECH
http://www.lpkf.com/products/rapid-pcb-prototyping/index.htm
http://www.t-tech.com/
A good used on will set you back us$5-10k
While there is no question they would do the job it's a little much for a garage tinkerer like myself.
Don't think the wife would approve.
My hunt lead me to this machine.
http://lumenlab.com/store/robloks/catalog/product/view/id/160/category/6
At the time it was still to be released.
Cost would have been us$1500 shipped.
More now with all the options available.
All I needed was something that did the job, no frills.
I do mostly surface mount so I don't have to drill.
The few through hole components become surface mount as well.
Then came across this unit.
http://cgi.ebay.com/ws/eBayISAPI.dll?ViewItem&item=120471713742

Laptop not included.
Not much online in the way of reviews but at that price it was worth a go.
All up us$780 shipped.
Just add your own PC.
I have only used it to make PCBs but it is capable of a lot more.
The full rundown of my experience here
http://www.cnczone.com/forums/showthread.php?t=84512
Do check out my blog to see what I will be doing with it :)
http://www.geekzone.co.nz/MrWestie