Its a Lenovo 21.5" AIO with an AMD A6-6310 CPU, 2x8GB RAM, AMD GPU etc. Running Win10 Home. 

The hardrive died so I replaced it.  Installed Fall update from scratch and the mouse glitches constantly.  Cant see any reason why.  I have updated the graphics and audio drivers as I saw on some forums they both can cause the issue. I also tried disabling the onscreen keyboard and touch screen as Ive had issues with them and weird programs in the past.

I know the machine was running fine previously so I decided replace the drive again with an SSD (for testing) and that made no difference. 

Next step was reformat and reinstall Windows 10 Creators Update.  Machines running perfectly well with that.

So it seems it doesnt like the fall update.  My customer (whos ditched the computer and given it to me - hence the ram upgrade etc) was saying before she got rid of it she was having problems with the mouse glitching as well.

I found Lenovo very nicely have some bios app that pops up a box in windows asking you to install their junk.  New bios later I found an option to disable it in the new bios. 

My next step will be do a manual update to the fall update and see if it does the same, if so I guess roll it back.  If anyone has any suggestions please let me know.  I did find somewhere that said their lan port was the cause but that would be very unusual Im thinking. 

By the mouse glitching I mean it'll freeze in place for a second every few seconds.