I had no trouble with getting the VS Ultimate ISO, but TFS crawled down. Fortunately everything was back to normal today and it's now up and running. I'm pleased to see that they fixed the blurry fonts that some of the betas had; I was worried that I wouldn't be able to use 2010 without getting a headache!
So far I've only tried one app in the RTM. Went from 0 errors and 0 warnings in 2008 to 66 errors and 13 warnings in 2010. Target framework not changed. Go figure.