2019 Novel Coronavirus Covid-19 Discussion

Forums › Health and fitness › 2019 Novel Coronavirus Covid-19 Discussion

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366 posts

Ultimate Geek

#2824327 4-Dec-2021 18:49

Oblivian: Wrecks kids cricket
Diverts police to manage traffic
More than 25 mixing in red area

Police said they needed to act to focus on balancing safety of those shopping and right to protest. and don't expect to lay charges.

About that enforcement...

I can't stand these people, but I prefer our way to say Melbourne and other places with riots and morons chanting day on day to get off on clashes with the cops.

I think the long game is the non confrontational game.

Just keep swimming...

HelloThere

169 posts

Master Geek

#2824329 4-Dec-2021 18:51

Batman That's what I've been saying since it was revealed that you don't actually need to validate. The tone has already been set by the PM before it went live. Hence vaccine passport should either be cancelled or it will cancel itself out when traders who enforce it lose money and those who avoid it make money.

In Hamilton today and no shops were checking the passes. Also no queues at any big retailer. I guess with one person per square meter a lot of business are not longer requiring people to line up anymore.

Oblivian

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#2824333 4-Dec-2021 19:01

HelloThere:
In Hamilton today and no shops were checking the passes. Also no queues at any big retailer. I guess with one person per square meter a lot of business are not longer requiring people to line up anymore.

When you say shops. Do you mean retail.

People seem to have forgotten what the framework covers

Social events, mixing and close quarters. Not general retail.

Hairdresser, makeup, hospo, dine in food.

Noone gets an added bonus to using it for retail under orange. So won't. Everyone gets landed with working out if people can mingle 1m apart. And roll with it. Id they get too full. They might go in/out. But I doubt many will.

https://covid19.govt.nz/traffic-lights/life-at-orange/shopping-and-services-at-orange/shopping-at-orange/

Hence the surprise at food joint's going takeaway only. It is an upgrade to level 3 standard from 2, all likely because they can't manage checking for passes.

HelloThere

169 posts

Master Geek

#2824335 4-Dec-2021 19:06

Yes I understand it's not retail but they do have cafes in malls and hardware retailers. The signs were up but no checking going on.

A couple of places I know are going takeaways only then they can operate under the retail guide. Shoppers come into the store to order then leave with their order and that way the workers don't need to be vaccinated.

Sup

366 posts

Ultimate Geek

#2824533 5-Dec-2021 00:46

I am looking forward to seeing combination therapies used during this fourth wave in Europe. They have to do something different. Eventually a Donald Trump style treatment course, where everything possible was thrown at his Covid episode, will be tried more widely.

At the moment that could look like treating an older person who has comorbidities with Paxlovid, Molnupirivir, Monoclonal antibodies, in one hit.

That would take some courage by prescribing physicians, however where the risk is high, why not try to head off hospital admissions which cost a lot more than these expensive drugs, to learn what combination therapy could achieve in high risk groups.

Eventually that could be extrapolated out for other groups when supply is there.

From memory Donald Trump was given the best available cocktail at the time, Remdesivir, Zinc, Vitamin D, Monoclonal antibodies, and steroids.

Imagine what they would have given that old unhealthy man now. Imagine what we could be offered in future, even the antidepressant Fluvoxamine and potentially other repurposed serotonin re-uptake inhibitors....Fluvoxamine is basically the first S.S.R.I. tried...there is a whole family of these medicines.

Just keep swimming...

neb

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#2824535 5-Dec-2021 00:53

Sup:
Eventually a Donald Trump style treatment course,

Wot, bleach and fish tank cleaner?

neb

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#2824536 5-Dec-2021 01:05

Sup:
Imagine what we could be offered in future, even the antidepressant Fluvoxamine and potentially other repurposed serotonin re-uptake inhibitors....Fluvoxamine is basically the first S.S.R.I. tried...there is a whole family of these medicines.

Wasn't Fluvoxamine used for its anti-inflammatory rather than SSRI properties, and the results were rather vague and screamed "needs further research"? It also required taking quite a high dose of an SSRI which may cause problems with some people, in particular something that puts you in an at-risk category for Covid19 may also be an at-risk category for high doses of SSRIs.

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Batman

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#2824554 5-Dec-2021 09:11

hippos got covid https://www.stuff.co.nz/world/europe/300470644/belgian-zoo-says-its-two-very-runnynosed-hippos-have-covid19

Sup

366 posts

Ultimate Geek

#2824570 5-Dec-2021 10:17

neb:
Sup:

Imagine what we could be offered in future, even the antidepressant Fluvoxamine and potentially other repurposed serotonin re-uptake inhibitors....Fluvoxamine is basically the first S.S.R.I. tried...there is a whole family of these medicines.

Wasn't Fluvoxamine used for its anti-inflammatory rather than SSRI properties, and the results were rather vague and screamed "needs further research"? It also required taking quite a high dose of an SSRI which may cause problems with some people, in particular something that puts you in an at-risk category for Covid19 may also be an at-risk category for high doses of SSRIs.

Hi, good questions. Certainly the jury is still out, the regulation of the immune response to dampen down inflamation is still a hypothesis in terms of Covid. Although this is a known mechanism with S.S.R.I.'s

Britain's NIH gave up on it after a small study, the latest noise is based off a larger study out of Brazil. It is certainly not a miracle drug, more likely it is a potential adjunct to other therapies with a possibly modest statistically significant impact on severity of illness.

Agreed on needing further research. The recommended course is a short course of ten days from memory. Regarding contraindications, this is always a limiting factor when treating people with commodities. The list of contraindications with this drug look fairly generic.

An interesting adverse reaction could be triggering of a manic episode. Especially in people with a mood disorder in the Bipolar group, I am talking here about people who may not know they have the disorder, and the ramifications of the wide off license use in a non psychiatric context on a population sized scale.

However this does not stop the use of S.S.R.I,s as a front line drug in the treatment of a first presentation with depression, every so often the patient is going to have UN-diagnosed Bipolar disorder (more likely milder form like Type 2) and be given an S.S.R.I in the depressive phase.

Nor do we worry about the use of say Prednisone which can also trigger mania, and has significant risk attached if not prescribed with diligence including titrating the dose carefully, I digress, but I am thinking about the risk versus benefits side of using some drugs....and the context in which some therapies that present risk, can be mitigated with a well researched knowlege base, which suggests perhaps, that we should investigate a possible role of one of these antidepressants in the treatment of Covid.

Just keep swimming...

Technofreak

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#2824575 5-Dec-2021 11:06

All PB Tech stores from Monday require a vaccine pass for entry.

Those without a vaccine Pass will have to use Click and Collect

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Technofreak

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#2824576 5-Dec-2021 11:07

neb:
Sup:

Eventually a Donald Trump style treatment course,

Wot, bleach and fish tank cleaner?

Donald who?😎

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FineWine

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#2824582 5-Dec-2021 11:54

This conversation made me curious to whether the low dose 10mg weekly Methotrexate I take for reactionary Arthritis (Reiter syndrome) would affect the Pfizer mRNA vaccine and/or a COVID infection.

Methotrexate is an immunosuppressant. It slows down your body's immune system and helps reduce inflammation.

It has come to light that those on immune-suppressing medications such as Methotrexate, where excluded from the initial Pfizer vaccine trials.

There is now appearing studies that show, in some cases, that taking Methotrexate, can reduce your antibody response to the vaccine. (https://www.everydayhealth.com/rheumatoid-arthritis/study-finds-people-on-methotrexate-mount-a-weaker-immune-response-to-a-covid-19-vaccine/) But the study does caution that those on immune-suppressing medications should still get vaccinated.

However, another study has found that taking these immune-suppressing medications for their anti-inflammatory effects may have benefits in providing protective effects against a SARS-CoV-2 infection. (https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-021-02464-4).

How will this affect our fight against SARS-CoV-2 and what will the long terms effects be ??

Interesting times ahead for the scientists. Maybe a Noble prize or two for some.

Whilst the difficult we can do immediately, the impossible takes a bit longer. However, miracles you will have to wait for.

Oblivian

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#2824584 5-Dec-2021 12:16

Palms mall in chc.

Signage at mains that all are welcome but some retailers may require pass.

Food court has an invisible fence of stickers on the ground and signs on table that entire dining area is for pass holders only. With the foodies checking by looks.

Sup

366 posts

Ultimate Geek

#2824587 5-Dec-2021 12:29

My sisters church are going to hold separate services for the unvaccinated who are in the minority, therefore can fellowship within the rules. The larger congregation have to scan passports.

We had a discussion about how this will evolve. Probably what will happen is that religions recommending similar practices will eventually see break away new Religions grounded on the principle of free agency and a probable strong anti science culture.

Just keep swimming...

Sup

366 posts

Ultimate Geek

#2824589 5-Dec-2021 12:40

FineWine:

This conversation made me curious to whether the low dose 10mg weekly Methotrexate I take for reactionary Arthritis (Reiter syndrome) would affect the Pfizer mRNA vaccine and/or a COVID infection.

Methotrexate is an immunosuppressant. It slows down your body's immune system and helps reduce inflammation.

It has come to light that those on immune-suppressing medications such as Methotrexate, where excluded from the initial Pfizer vaccine trials.

There is now appearing studies that show, in some cases, that taking Methotrexate, can reduce your antibody response to the vaccine. (https://www.everydayhealth.com/rheumatoid-arthritis/study-finds-people-on-methotrexate-mount-a-weaker-immune-response-to-a-covid-19-vaccine/) But the study does caution that those on immune-suppressing medications should still get vaccinated.

However, another study has found that taking these immune-suppressing medications for their anti-inflammatory effects may have benefits in providing protective effects against a SARS-CoV-2 infection. (https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-021-02464-4).

How will this affect our fight against SARS-CoV-2 and what will the long terms effects be ??

Interesting times ahead for the scientists. Maybe a Noble prize or two for some.

Interesting reading thanks. It seems counter intuitive that an immunosuppressant would have protective qualities with SARS CoV-1 however it just goes to show that there is more to consider in al things Covid.

Noble prizes will be interesting in a Covid context. The mRNA crowd probably should have received a bunch already...I see they were overlooked.

Just goes to show that bringing a new technology platform to billions of people to protect lives and likelihoods is not as important as understanding the receptors for temperature and touch.

Just keep swimming...

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