Geektastic:
The question you posed in no way suggested that the answer was necessarily in the vein of what was posted in response. All manner of things affect people every day. There's no particular reason to assume the question means what you have expanded it to mean.
On the basis of your expanded version, I would say almost nothing engenders that strong a reaction
You are quibbling. The question is what is something that really affects you? In this context really could be substituted with strongly. It suggests, quite clearly, something that elicits a powerful emotional reaction. If train schedules do that for you, welcome aboard.