Have successfully updated to iOS 5, working ok but a couple of issues... 

Reminders app. Cannot create a location dependant reminder. Should I be able to do this?

Notifications. Facebook app always notifies with TriTone sound, even tho I have changed it several times, restarted etc too. Facebook notifications seem to roll over twice and play the alert sound twice? 

Gestures. Bah, very disappointed about this one, was a feature I was very much looking forward to.

Wireless Syncing when connected via USB cable. Even though I plug in with USB cable,  syncing still appears to happen wirelessly. I guess turning off wifi before connecting will force it to sync wiredly.  

Newsstand App, cannot put this app into any folder! This is particularly annoying as all my apps are in folders, its unlikely I will use this app, I don't want it on my home screen! 

Also an AppleID gripe, my account goes back years and my username is xxx@mac.com. There's no way I can change this. I think this is a bit sucky as I cant use this email address, but I can't change it either.

Finally having a bit of difficulty with copy and paste! And does bold and italics etc only work in Mail?

I'm sure I'll find some more gripes.On the plus side, many new cool things.
I've also noticed that my iPad powers off significantly faster than it used to. 

Cheers,
Joseph