I'd like it to have dropbox-like capabilities, integrated into work desktops but accessible from home computers. Access controls on a file by file basis, not just at the folder level like some I've used. CIFS and/or WebDAV with some kind of SSL is pretty much essential.
I'm thinking about using Alfresco, as it can tie in with LDAP and Kerberos and looks pretty slick. Has anyone used it? Any other recommendations?