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sbiddle
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  #2757656 10-Aug-2021 08:02
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I probably read 10-15 medical papers most weeks about Covid and I've read a lot about the gap between doses in the past month. I really hope we don't go down the path, and that we actively discourage people from trying to do this themselves because I've seen a lot of people on social media in recent days trying to push out their appointments.

 

Yes there is a growing data to show that this may deliver a longer lasting antibody response, but we don't fully understand this. We know in general that longer gaps between vaccines offers a better immune response, and that many (use hepatitis as an example) can be up to 6 months. We do know that T-cell responses may be just as important (or potentially more important) than simply looking at antibodies. At the moment Pfizer still recommend 3 weeks, and the CDC emergency approval has not changed from that - what is going to be interesting is whether final approval sees this timeframe change.

 

Many countries look the approach of increasing the gap so that they could get more jabs in arms because a single jab offered far more protection than no jab. Delta has now changed that though, and to have good protection two jabs are essential. The sooner we can get both jabs in people's arms, the better.

 

Any discussion about whether antibodies might be weaker 12 months from now isn't that important in the greater scheme of things because it's pretty clear now that at least a single booster doses is going to be a thing. What is going to be really interesting is how vaccines such as Novavax may work as a booster.

 

 

 

 

 

 

 

 




clinty
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  #2757670 10-Aug-2021 08:26
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I have gone back and forward whether to push out my second jab to 5 or 6 weeks, but on balance have decided early full immunity is better - especially as there is a chance i may have to go airside once or twice a year for work

 

 

 

So three weeks it is :)

 

 

 

Clint

 

 

 

 


clinty
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  #2757688 10-Aug-2021 08:30
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sbiddle:

 

 

 

Any discussion about whether antibodies might be weaker 12 months from now isn't that important in the greater scheme of things because it's pretty clear now that at least a single booster doses is going to be a thing. What is going to be really interesting is how vaccines such as Novavax may work as a booster.

 

 

 

 

 

 

Am wondering if there is a set time frame on when we have to take the vaccines we ordered? I haven't seen any commentary on that?  If Novavax and AZ etc can be used as booster - and we don't have a time limit on when we need to receive them - then we are in a pretty good place for ongoing vaccination

 

 

 

Clint

 

edit: Spelling

 

 




Fred99
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  #2757689 10-Aug-2021 08:37
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sbiddle:

 

Many countries look the approach of increasing the gap so that they could get more jabs in arms because a single jab offered far more protection than no jab. Delta has now changed that though, and to have good protection two jabs are essential. The sooner we can get both jabs in people's arms, the better.

 

 

Within the proposed timeframe when doing this, a single jab does still offer far more protection against Delta than no jab.  Immunity against diagnosed infection with delta is nowhere near as good, but risk of hospitalisation or death is ~20x less. (for how long before immune response declines? - nobody knows).

 

Given that delta seems to be hospitalising ~10% of cases in Australia and with potential for massive rapid growth in case numbers without lockdowns, if getting jabs in arms is limited by supply or logistics and cases numbers are out of control, then prioritising getting first jabs in as many arms as possible is still a good strategy.

 

Another perspective, the single jab might only provide 35% immunity from infection, but that combined with the present 20% fully vaccinated might be enough to bring the R0 back to "containable" transmission rate similar to Alpha - which Australia & NZ managed to contain until now.


Fred99
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  #2757696 10-Aug-2021 08:51
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sbiddle:

 

What is going to be really interesting is how vaccines such as Novavax may work as a booster.

 

 

And despite the superficially very promising lab results announced by Novavax, the only way to find out is with clinical trials.

 

https://ir.novavax.com/2021-08-05-Novavax-Announces-COVID-19-Vaccine-Booster-Data-Demonstrating-Four-Fold-Increase-in-Neutralizing-Antibody-Levels-Versus-Peak-Responses-After-Primary-Vaccination

 

That increase in NAb levels is what you'd expect if the immune system was still strongly active from the original vaccination and "primed" to respond to infection.  The same result may be seen with a booster of any the vaccines.  It did boost Novavax share price.

 

 


Fred99
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  #2757710 10-Aug-2021 09:20
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65 of the 98 (or 92? - different news outlets reporting different figures)  Port workers tested have returned negative results so far.

 

Reti said vaccine hesitancy and misinformation would account for at most 15 percent of the population

 

Reti seems to be optimistic IMO - in the face of evidence that only 9/90 stevedores had been fully vaccinated, and 2 more had received only one shot.  That's a considerably lower % than the general population, and that group were supposed to be "priority".

 

FWIW a friend of mine works in the office at a NI port, he got both shots 3-4 months ago, 

 

 


Fred99
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  #2757751 10-Aug-2021 10:35
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clinty:

 

Am wondering if there is a set time frame on when we have to take the vaccines we ordered? I haven't seen any commentary on that?  If Novavax and AZ etc can be used as booster - and we don't have a time limit on when we need to receive them - then we are in a pretty good place for ongoing vaccination

 

 

We have on order:

 

10 million doses of Pfizer (about 7.5 million still on order / yet to be delivered)
2 million doses of Janssen.
10.72 doses of Novavax ("by the end of the 2021")
7.6 million doses of Astra Zeneca (possibly no problem getting delivery if it's needed)

 

There's no mention on MoH site about deferring delivery, but the government has been open with that if excess vaccines have been ordered and aren't needed, we'll donate (or transfer) the orders to countries who need them more - ie much of the rest of the planet for the medium term.

 

"When" Novavax or AZ can be used as a booster isn't really the question WRT timeframes for rolling out a plan when it's not yet fully proven whether it's needed or even works - despite what some people choose to believe.

 

I understand that Novavax have high hopes that their covid vaccine booster may be able to be included in with a "universal" flu vaccine they've got close to approval, so an annual one-shot flu/covid booster may be the way to go in the future.

 

 


 
 
 

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ezbee
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  #2757763 10-Aug-2021 10:57
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FTW 

 

Anti-vaccine protesters storm BBC HQ – years after it moved out
Group gain access to old Television Centre in west London, which is now mostly rented by ITV daytime shows
https://www.theguardian.com/world/2021/aug/09/confused-anti-vaccine-protesters-storm-bbc-hq-years-after-moved-out

 

""
“Not sure what protesters were hoping to achieve, but all they would’ve found was me, Jane, Nadia and Penny on Loose Women talking about the menopause,” she said.
""


DS248
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  #2757818 10-Aug-2021 11:23
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ezbee:

 

FTW 

 

... 

 

 

 

FTW? 

 

Seem to be several possibilities https://en.wiktionary.org/wiki/FTW

 

(as used, up to three of those could apply?)


ezbee
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  #2757838 10-Aug-2021 11:48
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DS248:

 

ezbee:

 

FTW 

 

... 

 

 

 

FTW? 

 

Seem to be several possibilities https://en.wiktionary.org/wiki/FTW

 

(as used, up to three of those could apply?)

 

 

Oh ! That does seem to have a lot of variations, even more here :-) 
https://www.urbandictionary.com/define.php?term=FTW 

Hollywood Squares , really ?

 

I was going for Safe For Work meanings.  
FTW 'For The Win' , maybe 'Free the Weed' would fit ( These people need to Chill ) 


Fred99
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  #2757903 10-Aug-2021 12:15
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Interesting video posted on twitter by NSW health:

 

Dr Richard Totaro, Co-Director of the Intensive Care Service at Sydney's Royal Prince Alfred Hospital, gives us an insight into the burden of COVID-19 on ICU wards, and explains the importance of getting vaccinated.

 


Fred99
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  #2757908 10-Aug-2021 12:23
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Sydney man in his 50s, ignores lockdown, travels to Byron area (NE NSW near Qld border) to look at real estate, waits until he's so sick from Covid that he needs to go to hospital, apparently doesn't "believe in the virus" - and is not cooperating with contact tracers who are trying to work out where he's been.

 

https://www.abc.net.au/news/2021-08-10/qld-covid-nsw-border-zones-authorities-high-alert-man-infectious/100360960

 

Result so far:

 


Technofreak
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  #2757933 10-Aug-2021 12:48
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The Tauranga port fiasco highlights to me that there is a severe lack of leadership around some of our Covid response.

 

It's been recognised and it's been well discussed that the border is where Covid will enter the country. Recognising this fact border workers were in the first group to be given the vaccine. The vaccinations for Group 1 started back in March. Five months later we still have at least one group of border workers where the vaccination rate is less about 8% of that work force. I'd wager this is not an isolated case.

 

When you compare this level of vaccination against the national average of around 16% it paints a pretty poor picture for a group that should have already had a high vaccination rate.

 

Where is the leadership to ensure workers in these critical locations have been vaccinated to the highest level possible? It appears that only now after this scare is there any attempt to find out who isn't vaccinated, and why. This should have been done months ago. 

 

Under current government directions there is still over seven weeks to go before all border workers have to vaccinated. Is over six months an acceptable time frame for this to have been done? I don't think so.

 

Someone is asleep at the wheel.





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Sideface
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  #2757938 10-Aug-2021 12:55
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Fred99:  Sydney man in his 50s, ignores lockdown, travels to Byron area (NE NSW near Qld border) to look at real estate, waits until he's so sick from Covid that he needs to go to hospital, apparently doesn't "believe in the virus" - and is not cooperating with contact tracers who are trying to work out where he's been. ...

 



 

Denial works very well - until it doesn't.  😕

 





Sideface


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  #2757939 10-Aug-2021 12:57
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Fred99:

Sydney man in his 50s, ignores lockdown, travels to Byron area (NE NSW near Qld border) to look at real estate, waits until he's so sick from Covid that he needs to go to hospital, apparently doesn't "believe in the virus" - and is not cooperating with contact tracers who are trying to work out where he's been.


https://www.abc.net.au/news/2021-08-10/qld-covid-nsw-border-zones-authorities-high-alert-man-infectious/100360960


Result so far:




People have autonomy to not get treatment. If they don't want treatment don't waste money on hospital care.

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